Recent studies suggest that dietary factors, especially unsaturated fatty acids, may influence systemic lupus erythematosus (SLE) due to their anti-inflammatory properties. This meta-analysis aimed to assess the relationship between unsaturated fatty acid consumption and SLE risk, progression, and clinical manifestations. By reviewing studies up to January 2024, the analysis included randomized controlled trials and case-control studies, focusing on SLE activity and inflammation markers, such as SLE Disease Activity Index (SLEDAI) and the British Isles Lupus Assessment Group (BILAG) index.
The meta-analysis of 10 studies revealed that higher unsaturated fatty acid intake was linked to a significant reduction in SLEDAI scores, indicating improved disease activity. Additionally, unsaturated fatty acids positively impacted HDL cholesterol levels but did not significantly affect inflammatory markers like IL-6 or other lipid components. These findings suggest that unsaturated fatty acids could benefit SLE management, particularly by improving disease activity and lipid profiles. Further research is needed to explore underlying mechanisms and refine dietary recommendations.
Reference: Wang B, Wang H, Huang J, et al. Association between Unsaturated Fatty Acid-Type Diet and Systemic Lupus Erythematosus: A Systematic Review with Meta-Analyses. Nutrients. 2024 Jun 20;16(12):1974. doi: 10.3390/nu16121974. PMID: 38931327; PMCID: PMC11206385.
