A recent study investigated the involvement of RPL9 and TIFA in scalp psoriasis, assessing their potential as therapeutic targets. Using the Gene Expression Omnibus database, researchers conducted analyses to identify key genes and their interactions in scalp psoriasis. They discovered that RPL9 and TIFA were highly expressed in scalp psoriasis tissues and in certain keratinocytes. Knocking down RPL9 not only reduced cell proliferation but also significantly decreased TIFA expression and the secretion of the inflammatory cytokine TNF-α. These results indicate that RPL9 plays a crucial role in scalp psoriasis and could be a promising target for its treatment, offering new directions for clinical therapies.
Reference: Liu S, Zhuang Z, Liu F, et al. Identification of potential biomarkers and infiltrating immune cells from scalp psoriasis. Gene. 2024 Jan 30;893:147918. doi: 10.1016/j.gene.2023.147918. Epub 2023 Oct 21. PMID: 37871808.
