In a recent study, researchers aimed to develop experimental models of skin inflammation in humans to predict treatment responses for inflammatory skin diseases like atopic dermatitis (AD) and psoriasis. The researchers topically or intradermally administered four common sensitizers (dust mite, diphencyprone, nickel, and purified protein derivative) to the skin of 40 healthy patients and then evaluated the skin hypersensitivity response using various techniques.
The results showed that all four sensitizers induced strong increases in cellular infiltrates (T-cells and dendritic cells) compared to untreated skin. Researchers concluded that diphencyprone induced the most robust immune response across various pathways and closely mimicked the barrier defects seen in AD and psoriasis. These findings contribute to understanding the pathogenesis of inflammatory skin diseases and may aid in predicting treatment responses for patients with AD and psoriasis.
Reference: Pavel AB, Del Duca E, et al. Delayed type hypersensitivity reactions to various allergens may differently model inflammatory skin diseases. Allergy. 2023 Jan;78(1):178-191. doi: 10.1111/all.15538. Epub 2022 Oct 8. PMID: 36178084.
