Researchers investigated the roles of RPL9 and TIFA in scalp psoriasis to develop better clinical treatments. By analyzing data from the Gene Expression Omnibus database and using tools like STRING and Cytoscape, the study identified RPL9 as a significant gene. Findings showed that RPL9 and TIFA are overexpressed in scalp psoriasis. Reducing RPL9 levels led to decreased cell proliferation, lower TIFA expression, and reduced TNF-α secretion. The study concludes that RPL9 is a promising target for scalp psoriasis treatment due to its critical role in the disease’s progression.
Reference: Liu S, Zhuang Z, Liu F, et al. Identification of potential biomarkers and infiltrating immune cells from scalp psoriasis. Gene. 2024 Jan 30;893:147918. doi: 10.1016/j.gene.2023.147918. Epub 2023 Oct 21. PMID: 37871808.
