A recent review synthesizes current research on biomarkers for bipolar disorder in older adults, focusing on genetic, neuroimaging, and biochemical indicators. A systematic search of the PubMed MEDLINE, PsycINFO, and Web of Science databases identified 26 relevant studies that met inclusion criteria, such as a study population with an average age of 50 years or older. Genomic markers pointed to alterations in serotonin metabolism and angiogenesis-related gene expression, while peripheral blood markers suggested associations with low-grade inflammation, axonal damage, endothelial dysfunction, and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis.
Neuroanatomical markers in the studied population indicated dysfunction in the frontal cortex, neuronal loss in the anterior cingulate cortex, and reduced hippocampal volume. Some biomarkers, like neurofilaments, have potential utility in differential diagnosis, while others such as homocysteine and brain-derived neurotrophic factor (BDNF) could help in disease staging and monitoring treatment outcomes. The review highlights the significance of identifying reliable biomarkers to improve diagnosis, tailor treatment choices, and monitor the efficacy of interventions in elderly bipolar disorder patients.
Reference: Chancel R, Lopez-Castroman J, Baca-Garcia E, Mateos Alvarez R, Courtet P, Conejero I. Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review. Curr Psychiatry Rep. 2024 Mar;26(3):78-103. doi: 10.1007/s11920-024-01483-7. Epub 2024 Mar 12. PMID: 38470559.
Read More > https://pubmed.ncbi.nlm.nih.gov/38470559/
