Using next-generation sequencing, researchers identified potential genetic links to the onset of psoriasis. In addition to next-generation sequencing, researchers used a customized multigene panel to investigate germline alterations associated with psoriasis. Analyzing a family, variants linked to psoriasis were found in the TRAF3IP2 gene, along with a missense variant in the NAT9 gene. The use of multigene panels in psoriasis may aid in identifying new susceptibility genes and facilitating early diagnoses, especially in affected families.
Reference: Nunziato M, Balato A, Ruocco A, et al. A Familial Novel Putative-Pathogenic Mutation Identified in Plaque-Psoriasis by a Multigene Panel Analysis. Int J Mol Sci. 2023 Mar 1;24(5):4743. doi: 10.3390/ijms24054743. PMID: 36902182; PMCID: PMC10003515.
