A study looked at how dysbiosis, an imbalance in the gut microbiota, is linked to various dermatological conditions such as psoriasis, atopic dermatitis, and systemic lupus erythematosus. Microbiota-derived molecules known as metabolites play a key role in maintaining balance in the body. Each group of metabolites has specific receptors and ways of influencing bodily functions. Researchers emphasize the significance of these metabolites in dermatological conditions, particularly their impact on the immune system. Changes in immune cell profiles and cytokine imbalances are common in skin diseases like psoriasis and atopic dermatitis. The study concluded that targeting the production of microbiota metabolites could offer a new approach for treating immune-mediated dermatological diseases.
Reference: Stec A, Sikora M, Maciejewska M, Paralusz-Stec K, Michalska M, Sikorska E, Rudnicka L. Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases. Int J Mol Sci. 2023 Feb 9;24(4):3494. doi: 10.3390/ijms24043494. PMID: 36834904; PMCID: PMC9961773.
