Atypical Parkinsonian syndromes, such as DLB, MSA, PSP, and CBD, present diagnostic and management hurdles due to their varied protein deposition and clinical features. DLB, characterized by synuclein deposition in neocortical neurons, initially shows dementia followed by Parkinsonism, while MSA, marked by synuclein deposition in oligodendrocytes, primarily affects autonomic function alongside Parkinsonism or cerebellar ataxia. PSP and CBD, tauopathies, exhibit distinct clinical features like supranuclear gaze palsy and asymmetrical
