Researchers analyzed RNA sequencing and phosphopeptide profiling of left ventricular tissue from 93 heart failure patients (25 responders and 68 non-responders) and 12 non-failing donor hearts. The analysis identified numerous differentially regulated transcripts and phosphopeptides in cardiac tissue, with a unique signature distinguishing responders. Key pathways affected were cell cycle regulation and extracellular matrix/focal adhesions. This study, the first to use multiple-omics platforms to characterize changes in the non-failing and failing human heart, identified molecular markers that define patients capable of myocardial recovery. Researchers concluded that these findings may have implications for patient selection in advanced heart failure therapies and the identification of new therapeutic targets.
Reference: Drakos SG, Badolia R, Makaju A, et al. Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support. Circulation. 2023 Jan 31;147(5):409-424. doi: 10.1161/CIRCULATIONAHA.121.056600. Epub 2022 Nov 30. PMID: 36448446; PMCID: PMC10062458.
