A 22-week diet program combining Mediterranean and ketogenic elements showed promising results in patients with psoriasis and psoriatic arthritis, indicating potential benefits in disease activity indices. The researchers aimed to evaluate the efficacy of these diets in managing inflammation beyond weight loss. The research involved 16 subjects who met specific criteria, including a BMI of 30 kg/m² or more and continuous systemic treatment. They were assessed for Psoriasis Area and Severity Index (PASI) score improvement and joint activity.
Participants were randomly assigned to either a Mediterranean or ketogenic diet for 8 weeks, followed by a 6-week washout period and then switched to the alternate diet. Key findings included major reductions in BMI, weight, fat mass, waist circumference, and visceral fat levels for both diets. Specifically, the ketogenic diet was associated with significant decreases in PASI scores and inflammatory markers (IL-6, IL-17, DAPSA, and IL-23), while the Mediterranean diet did not show significant changes. The research underscores the potential role of dietary interventions in treating auto-inflammatory disorders.
Reference: Smith T. Psoriasis, Psoriatic Arthritis Patients Benefited from Mediterranean-Ketogenic Diet Program. HCPLive. Published March 22, 2024. Accessed April 8, 2024. https://www.hcplive.com/view/psoriasis-psoriatic-arthritis-patients-benefited-from-mediterranean-ketogenic-diet-program
