Systemic lupus erythematosus is a multisystem autoimmune disease caused by immune system dysfunction, and it differs from early-onset SLE, with less major organ involvement (e.g., nephritis) but greater long-term damage, likely due to atypical symptoms and delayed diagnosis. Multimorbidity is common, including osteoporosis, sarcopenia, atherosclerosis, diabetes, hypertension, and coronary artery disease. Diagnostic challenges and overlap with Sjögren’s disease further complicate management. Treatment should consider age-related factors like declining kidney function, osteoporosis, and multimorbidity, while minimizing prolonged steroid use. Non-pharmacological approaches alongside immunosuppression can help manage pain, fatigue, depression, and cardiovascular health, ultimately improving quality of life and long-term outcomes.
Reference: Mruthyunjaya P, Ahmed S, Botabekova A, et al. Late-onset Systemic Lupus Erythematosus. Rheumatol Int. 2025 Jan 15;45(1):29. doi: 10.1007/s00296-024-05784-1. PMID: 39812833.
