Researchers sought to uncover the epigenetic mechanism underlying visceral hypersensitivity in patients with irritable bowel syndrome with diarrhea (IBS-D). The research involved analyzing differentially expressed microRNAs (miRNAs), messenger RNAs (mRNAs), and proteins in IBS-D patients compared to healthy volunteers. Results indicated 33 differentially expressed miRNAs in IBS-D, with five confirmed. The study found significant differences in the expression of specific miRNAs in the intestinal tissues of IBS-D patients involved in regulating various molecules and signaling pathways, contributing to the complex mechanism of visceral hypersensitivity in IBS-D at multiple levels.
Reference: Lu Y, Chai Y, Qiu J, et al. Integrated omics analysis reveals the epigenetic mechanism of visceral hypersensitivity in IBS-D. Front Pharmacol. 2023 Mar 16;14:1062630. doi: 10.3389/fphar.2023.1062630. PMID: 37007011; PMCID: PMC10064328.
