Patients with psoriatic arthritis (PsA) demonstrated increased aortic stiffness compared with controls, as revealed by the largest carotid-femoral pulse wave velocity (cfPWV)/PsA cohort to date. The study identified disease duration as the primary independent predictor of elevated aortic stiffness, followed by traditional cardiovascular risk factors. The research emphasized the need for precise methodologies to measure cardiovascular risk in patients with PsA. Despite cfPWV’s consistent prediction of cardiovascular risk in the general population, its application in PsA remains limited.
The study analyzed cfPWV values, Systemic Coronary Risk Evaluation, and various clinical factors in 150 patients with PsA and 88 healthy controls. Patients with PsA had significantly higher cfPWV than controls, even after adjusting for confounders. Disease duration, age, systolic arterial pressure, and glomerular filtration rate were notable factors associated with cfPWV. The research highlighted that aortic stiffness reflects the long-term effects of cardiovascular risk factors and inflammation-related vascular damage, suggesting cfPWV as a useful tool for identifying high cardiovascular risk in patients with PsA.
Reference: Pine L. Psoriatic Arthritis Linked to Elevated Aortic Stiffness. HCPLive. Published June 4, 2024. Accessed July 8, 2024. https://www.hcplive.com/view/psoriatic-arthritis-linked-to-elevated-aortic-stiffness
Link: https://www.hcplive.com/view/psoriatic-arthritis-linked-to-elevated-aortic-stiffness
