The way the gut microbiome and host gene regulation interact is unclear. Researchers developed a machine learning-based framework to look at paired host transcriptomic and gut microbiome profiles from colonic mucosal samples of patients with irritable bowel syndrome (IBS) and other gastrointestinal diseases. The framework is applicable to other diseases for the identification of host gene–microbiome associations that may influence disease outcomes, and the researchers also identified a set of host genes and pathways that play a role in gastrointestinal inflammation.
Reference: Priya, S., Burns, M.B., Ward, T. et al. Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration. Nat Microbiol 7, 780–795 (2022). https://doi.org/10.1038/s41564-022-01121-z
READ MORE
