Researchers of a recent study discovered hidden aspects of inflammation in psoriasis that may explain the systemic effects and comorbidities associated with the condition. By examining skin samples from individuals with psoriasis, they found altered cellular clusters and increased gene activity in metabolic pathways. These findings could help explain why psoriasis can trigger other seemingly unrelated conditions such as heart disease, inflammatory bowel disease, and type 2 diabetes. The researchers noted the need for further analysis to better understand the molecular signals that predict the development of severe psoriasis and related disorders. The study provides valuable insights into the cellular and molecular features of both healthy and diseased skin, and future research will involve larger patient groups to explore individual differences in response to treatment and spontaneous clearance of the disease.
Reference: Smith T. Psoriasis Found to Exhibit Altered Cellular Clusters, Higher Gene Activity in Metabolic Pathways. HCP Live. Published June 5, 2022. Accessed June 14, 2023. https://www.hcplive.com/view/psoriasis-found-exhibit-altered-cellular-clusters-higher-gene-activity-in-metabolic-pathways
