A recent study using the TriNetX database explored whether psoriatic arthritis (PsA) in patients with psoriasis (PsO) is primarily genetically predetermined. Three retrospective cohort studies were conducted to assess the risk of developing PsA in patients with PsO with type 2 diabetes mellitus (DM), smoking history, and the combination of both factors. The results showed that patients with PsO with type 2 DM had an elevated risk of developing PsA (hazard ratio [HR], 1.11), and the combined effect of type 2 DM and smoking further increased this risk (HR, 1.31). Similarly, patients with PsO who smoked had a higher risk of PsA (HR, 1.11), with the combined effect of smoking and type 2 DM yielding an HR of 1.28.
The findings indicate that intrinsic factors, such as genetic predisposition, may play a more significant role in the development of PsA in patients with PsO than external factors like type 2 DM and smoking. Patients with PsO with both type 2 DM and a smoking history did not show a significantly increased risk of developing PsA (HR, 1.05), though the combined result revealed a slightly higher risk (HR, 1.15). These results suggest the need for further research on genetic differences between PsO and PsA as potential risk indicators, rather than focusing solely on phenotypic distinctions.
Reference: Huo AP, Liao PL, Leong PY, Wei JC. From psoriasis to psoriatic arthritis: epidemiological insights from a retrospective cohort study of 74,046 patients. Front Med (Lausanne). 2024;11:1419722. doi: 10.3389/fmed.2024.1419722.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236760/
