In a recent study, researchers looked at chronic kidney disease (CKD) and the ways excessive levels of glucocorticoids, such as cortisol, can cause similar health issues as CKD. The review highlights the dysregulation of cortisol in CKD and its significance for adverse clinical outcomes. It suggests that individuals with CKD may experience subclinical hypercortisolism, characterized by flattened diurnal decline of cortisol levels, impaired negative feedback regulation, and reduced cortisol clearance. Observational studies have reported an association between cortisol levels and adjusted all-cause mortality in patients with end-stage renal failure. The researchers propose recommendations for future research, including exploring therapeutic strategies to correct or reverse cortisol dysregulation to reduce complications associated with CKD.
Reference: Sagmeister MS, Harper L, Hardy RS. Cortisol excess in chronic kidney disease – A review of changes and impact on mortality. Front Endocrinol (Lausanne). 2023 Jan 17;13:1075809. doi: 10.3389/fendo.2022.1075809. PMID: 36733794; PMCID: PMC9886668.
READ MORE > https://pubmed.ncbi.nlm.nih.gov/36733794/
