A recent, randomized, controlled crossover trial included 16 patients divided into ketogenic and Mediterranean diet groups, each following the diet for 8 weeks with a 6-week washout period before switching. The ketogenic group showed significant decreases in interleukin (IL)-6, IL-23, Disease Activity in Psoriatic Arthritis (DAPSA) scores, and Psoriasis Area Severity Index scores. A subsequent study with 20 patients found a very low-calorie ketogenic diet led to a median reduction of 3 body mass index (BMI) points and improved pain, working ability, and disease activity by week 9, along with better insulin levels and lipid profiles. While no differences were noted in axial disease measures and inflammatory markers, BMI reduction correlated with decreased DAPSA scores and improved work productivity. Older patients and those with metabolic syndrome had variable responses, with baseline tumor necrosis factor-alpha levels predicting better weight loss outcomes.
The study supports previous findings that both Mediterranean and ketogenic diets improve disease activity in patients with psoriasis and psoriatic arthritis, with greater benefits from the ketogenic diet.
Reference: Pine L. Ketogenic Diet Intervention Improves Psoriatic Arthritis Symptoms. HCP Live. Published July 19, 2024. Accessed August 1, 2024. https://www.hcplive.com/view/ketogenic-diet-intervention-improves-psoriatic-arthritis-symptoms
Link: https://www.hcplive.com/view/ketogenic-diet-intervention-improves-psoriatic-arthritis-symptoms
