A review provided an in-depth overview of Clostridioides difficile infection (CDI), a major concern in nosocomial infections. CDI presents complex challenges for clinicians due to the evolving nature of the bacterium. The review discusses epidemiological aspects, predisposing factors, clinical manifestations, and diagnostic tools. It highlights new therapeutic strategies, including monoclonal antibodies and live biotherapeutic products, essential for effective treatment. The review also explores future options under study, such as bacteriophages, vaccines, and antibiotic inhibitors.
Surveillance and prevention strategies are emphasized as crucial in limiting the spread of CDI. The review underscores the importance of understanding these strategies to fully utilize the benefits of emerging therapies. By providing a comprehensive overview, the review aims to equip clinicians with the knowledge necessary to tackle CDI effectively and explore promising future prophylactic and therapeutic options.
Reference: Di Bella S, Sanson G, Monticelli J, et al. Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options. Clin Microbiol Rev. 2024 Feb 29:e0013523. doi: 10.1128/cmr.00135-23. Epub ahead of print. PMID: 38421181.
