A recent single-center retrospective study found that patients with juvenile idiopathic arthritis (JIA) who had active disease at 12 and 24 months were more likely to be older at diagnosis and have specific JIA subtypes, such as psoriatic JIA, enthesitis-related JIA, or polyarticular rheumatoid factor-negative JIA. Researchers analyzed data from 1151 patients treated at Seattle Children’s Hospital between 2004 and 2018, and noted that older children (over 5 years) had a 40% to 45% higher prevalence of active disease at 12 months compared to younger patients. Active disease at 3 months was linked to a higher prevalence of disease at both 12 and 24 months.
The study also observed that patients diagnosed between 2013 and 2018 had a 25% lower prevalence of active disease at 12 months compared to those diagnosed between 2004 and 2008. This reflects the impact of increased availability of biologic disease-modifying antirheumatic drugs. However, despite the advancements in treatment, the predictors of disease activity remained consistent across different time periods. The researchers highlighted the need for further studies to identify stronger predictors of active disease as new therapeutic options continue to emerge.
Reference: Pine L. Active Disease at 3 Months Predicts Poorer Long-Term Outcomes in JIA. HCP Live. Published July 8, 2024. Accessed September 3, 2024. https://www.hcplive.com/view/active-disease-at-3-months-predicts-poorer-long-term-outcomes-in-jia
Link: https://www.hcplive.com/view/active-disease-at-3-months-predicts-poorer-long-term-outcomes-in-jia
