Researchers of a recent study investigated the risk of developing psoriatic arthritis (PsA) among patients with various forms of psoriasis, considering sex and ethnicity. Using over 120 million electronic health records from the TriNetX database, researchers conducted global retrospective cohort studies. They identified cohorts with psoriasis vulgaris (Pso), pustulosis palmoplantaris (PPP), and generalized pustular psoriasis (GPP) using ICD-10 codes and employed propensity score matching to ensure robust comparisons.
The study revealed significant variations in PsA risk among different psoriasis types. Pso had the highest risk (hazard ratio [HR] 87.7), followed by GPP (HR 26.8) and PPP (HR 15.3). The analysis also showed sex and ethnicity disparities, with female patients with Pso having a slightly higher risk than males (HR 1.1), and White patients with Pso more likely to develop PsA than Black or African American patients (HR 1.3). These findings highlight the importance of incorporating sex and ethnicity into PsA risk assessments to improve monitoring and interventions for patients with psoriasis.
Reference: Gershater B, Bieber K, Vorobyev A, et al. Differential risks of psoriatic arthritis development in patients with varied psoriasis manifestations: a sex- and ethnicity-specific analysis. Front Med (Lausanne). 2024;11:1385491. doi: 10.3389/fmed.2024.1385491.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224429/
