In a review article, authors looked into the microbiome in early-life stages that may impact the occurrence of Clostridioides difficile (C. difficile), as well as protection from disease manifestation in infants. The authors of this article also examined early-life colonization, and if features in adult microbiota that allow and restrict C. difficile are present during that time. Environmental factors linked to heightened rates of C. difficile colonization in infants were discussed, but the authors highlighted that there is not a single factor related with an increase of susceptibility. In the conclusion of this article, it is noted that in vivo models are needed to conduct controlled longitudinal studies to determine if C. difficile-associated dysbiosis in the stages of early life affects host development.
Reference: Semon AK, Keenan O, Zackular JP. Clostridioides difficile and the Microbiota Early in Life. J Pediatric Infect Dis Soc. 2021;10(Supplement_3):S3-S7. doi:10.1093/jpids/piab063
