A recent study involving more than 361,000 individuals from the UK and nearly 4,000 psoriasis patients from China examined the relationship between white blood cells and psoriasis. The study found that high levels of certain white blood cells, specifically monocytes, neutrophils, and eosinophils, increased the risk of psoriasis. Specifically, eosinophils showed a clear causal relationship with psoriasis severity. Additionally, while certain ratios of these immune cells were related to psoriasis risk and severity, they didn’t directly cause the disease. The findings reveal an important association between circulating leukocytes and psoriasis, which is instructive for the clinical practice of psoriasis treatment.
Reference: Zhou G, Ren X, Tang Z, et al. Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data. Front Immunol. 2023 Feb 14;14:1043380. doi: 10.3389/fimmu.2023.1043380. PMID: 36865550; PMCID: PMC9971993.
