A study aimed to investigate the prevalence of sucrase-isomaltase deficiency (SID)—a condition where the enzyme sucrase-isomaltase, important for digesting sucrose, is lacking—in patients with presumed irritable bowel syndrome with diarrhea/abdominal pain/bloating (IBS-D/M). Among 31 participants, 35% had SID. Symptoms included diarrhea (63.6%), abdominal pain (45.4%), and bloating (36.4%). Patients with SID had less abdominal pain compared to those without (Odds Ratio: 0.16). The study suggests that SID should be considered in patients with IBS-like symptoms and more research is needed to explore this condition’s features and dietary impacts.
Reference: Kim SB, Calmet FH, Garrido J, Garcia-Buitrago MT, Moshiree B. Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome. Dig Dis Sci. 2020 Feb;65(2):534-540. doi: 10.1007/s10620-019-05780-7. Epub 2019 Sep 6. PMID: 31493040.
