TNFα-inhibitor-induced psoriasis is mediated by the type-I interferon pathway. In a study that may help identify therapeutic targets for more effective psoriasis management, researchers found that small plaque psoriasis possesses a definite morphology and immune-phenotype mediated by the type-I interferon pathway.
Reference: Khosravi-Hafshejani T, Ghoreishi M, Vera Kellet C, et al. Small plaque psoriasis re-visited: A type of psoriasis mediated by a type-I interferon pathway. Exp Dermatol. 2022 May;31(5):753-763. doi: 10.1111/exd.14513. Epub 2021 Dec 13. PMID: 34890074.
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