Researchers Find No Significant Effect of Oral Vitamin D Supplements on Psoriasis Severity During Winter Months

Researchers present the results of a randomized, double-blind, placebo-controlled clinical trial that aimed to examine the effect of oral vitamin D supplementation on psoriasis severity throughout the winter. The trial was conducted over two winter seasons, and participants were adults from the general population in Tromsø, Norway, with active plaque psoriasis and low levels of 25-hydroxyvitamin D. The trial showed that vitamin D supplementation did not impact psoriasis severity, possibly due to low baseline severity scores and lower-than-expected increases in 25(OH)D levels in the intervention group. These findings suggest that topical vitamin D analogues remain the preferred treatment for psoriasis, and further studies are needed to determine the optimal dose and duration of vitamin D supplementation for patients with psoriasis.

Reference: Jenssen M, Furberg AS, Jorde R, Wilsgaard T, Danielsen K. Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels: A Randomized Clinical Trial. [published online ahead of print, 2023 Mar 29]. JAMA Dermatol. 2023;e230357. doi: 10.1001/jamadermatol.2023.0357.

Link: https://jamanetwork.com/journals/jamadermatology/article-abstract/2802780?resultClick=1